This paper examines the foundational ethical, philosophical, and civilizational differences between the African worldview and the dominant Western worldview. Drawing on the insights of social philosopher and economist Manuel Tacanho in his paper Africonomics: A School of African Philosophical and Economic Thought, it affirms that the African worldview is intrinsically theist, principled, nonrivalrous, and nonaggressive, while the Western worldview remains shaped by materialism, racialism, rivalry, and systemic violence. This contrast—the distinctly human and principled nature of the African worldview—makes it morally and civilizationally superior to the animalistic Western worldview. The paper critiques the Western paradigm’s grounding in Darwinian evolutionary theory, Social Darwinism, and racism, highlighting the destructive impact of these ideologies on worldwide human relations within and among nations. It concludes that the African worldview, as articulated in Africonomics, offers an ethical, constructive, and civilized framework for structurally just socioeconomic order and human flourishing—one aligned with reality and grounded in the natural-moral law principles of truth, justice, and nonaggression.